Vascular health is crucial for longevity and healthspan, and a shift towards a more preventative approach is reshaping the field of cardiovascular healthcare. Dr. Michael Twyman, a preventive cardiologist, emphasizes the importance of endothelial glycocalyx and endothelium health in maintaining cardiovascular wellness. The endothelial glycocalyx is a protective gel-like layer that covers the inner lining of blood vessels and plays a vital role in maintaining healthy blood flow by preventing the adhesion of lipoproteins and other particles to the artery walls. Dysfunction of the glycocalyx is considered the root cause of cardiovascular disease.
In addition to glycocalyx health, Dr. Twyman highlights the key role of nitric oxide, circadian biology, and the oral microbiome in cardiovascular health. Nitric oxide is a signaling molecule that relaxes smooth muscles and improves blood flow. It is produced by the endothelium in response to the stimulation of the glycocalyx. Circadian biology, or the internal body clock, affects various physiological processes, including the release of hormones and the regulation of sleep-wake cycles. Disruptions in circadian rhythms can negatively impact cardiovascular health.
The oral microbiome also plays a crucial role in cardiovascular health as it influences the production of nitric oxide. Bacteria in the oral cavity can convert nitrates from foods, such as green leafy vegetables and beets, into nitrites, which can be further converted into nitric oxide. Disrupting the oral microbiome, through the use of antiseptic mouthwash or acid-blocking medications, can inhibit the production of nitric oxide.
To improve cardiovascular health, Dr. Twyman recommends a multi-faceted approach that includes optimizing the endothelial glycocalyx and endothelium, managing oxidative stress and inflammation, and addressing the lipoprotein equation. He suggests using supplements that support healthy glycocalyx function, such as rhamnan sulfate, which can be found in products like Arterosil. Additionally, he recommends nitric oxide-promoting supplements like Vascanox to enhance nitric oxide production. However, Dr. Twyman emphasizes that lifestyle factors, such as stress management, sleep optimization, and a healthy diet, should be prioritized before turning to supplements.
In terms of evaluating cardiovascular health, Dr. Twyman highlights the importance of comprehensive lab testing, such as urine microalbumin and creatinine tests to assess glycocalyx dysfunction. He also recommends markers of oxidative stress, inflammation, and lipoproteins to determine the risk of cardiovascular events.
Dr. Twyman acknowledges that genetic factors can influence cardiovascular health and lifespan. While genetics may play a role, a comprehensive approach that focuses on the four pillars of health (nutrition, exercise, stress management, and sleep) can help individuals improve their cardiovascular health and extend their healthspan.
In conclusion, optimizing cardiovascular health requires a preventive and holistic approach that addresses the health of the endothelial glycocalyx and endothelium, supports nitric oxide production, and promotes overall well-being through lifestyle interventions. Regular testing and tracking on the endothelial glycocalyx and nitric oxide function can help monitor progress and guide interventions.
Source Article: https://www.drkarafitzgerald.com/2023/07/25/mastering-cardiovascular-longevity-glycocalyx-biohacking-for-optimal-heart-health/
